Alisa Brunovna Freindlikh was born on December 8, 1934, in Leningrad, USSR (now St. Petersburg, Russia). Her father, named Bruno Frejndlikh, was a notable actor. Alisa Freindlikh graduated from Leningrad Institute of Theatre, Music, and Cinematography in 1957.

From 1961-1983 Alisa Freindlikh was a permanent member of the Leningrad Theatre of Lensovet under directorship of her husband Igor Vladimirov. She was the leading star of that theatre and her stage partners were such actors as Georgi Zhzhyonov, Aleksey Petrenko, Sergey Migitsko, Anatoliy Ravikovich, Mikhail Devyatkin, Mikhail Boyarskiy, Larisa Luppian, Galina Nikulina, Vera Ulik, Leonid Dyachkov, Valeri Kuzin, Yefim Kamenetsky, Leila Kirakosian, Aleksandr Estrin, Petr Shelokhonov, and other notable Russian actors.

Alisa Freindlikh made a stellar film career in collaboration with director Eldar Ryazanov. Her most memorable work was the female lead opposite Andrey Myagkov in Sluzhebnyy roman (1977). She also brilliantly played a supporting role in Zhestokiy romans (1984), a Ryazanov's adaptation of the 19th century story by Aleksandr Ostrovskiy. In 1983 Alisa Freindlikh was designated the People's Artist of the USSR. That same year she divorced from her husband Igor Vladimirov, and soon left the Theatre of Lensovet.

Since 1984 Alisa Freindlikh has been a permanent member of Bolshoi Drama Theatre (BDT) in St. Petersburg (Leningrad) under directorship of Georgi Tovstonogov. There her stage partners were such stars as Kirill Lavrov, Oleg Basilashvili, Lyudmila Makarova, Svetlana Kryuchkova, Zinaida Sharko, Valentina Kovel, Sergey Yurskiy, Nikolay Trofimov, Vladislav Strzhelchik, Yevgeni Lebedev, Georgiy Shtil, Vsevolod Kuznetsov, Vadim Medvedev, Yuriy Demich, Leonid Nevedomsky, Gennadiy Bogachyov, Andrey Tolubeev, and many other notable Russian actors.

In 2004, on her 70th birthday, Alisa Freindlikh was visited in her home by the Russian president Vladimir Putin. She was decorated for her achievements as an actress in film and theatre. Alisa Freindlikh is residing in St. Petersburg, Russia.